abstract：:There is little evidence for the involvement of microRNAs (miRs) in the regulation of circadian rhythms, despite the potential relevance of these elements in the posttranscriptional regulation of the clock machinery. The present work aimed to identify miRs targeting circadian genes through a predictive analysis of con...

journal_title：Journal of biological rhythms

authors： Figueredo Dde S,Barbosa MR,Gitaí DL,de Andrade TG

更新日期：2013-04-01 00:00:00

abstract：:In vertebrates, reproductive output often increases with age. Unlike older birds, first-year photoperiodic birds lack experience with the reproductively stimulatory effects of long day lengths (photostimulation). We examined whether age-related differences in annual reproductive development could be partially attribut...

journal_title：Journal of biological rhythms

authors： Salvante KG,Dawson A,Aldredge RA,Sharp PJ,Sockman KW

更新日期：2013-02-01 00:00:00

abstract：:In mammals, the suprachiasmatic nucleus (SCN) is the central pacemaker organizing circadian rhythms of behavior and physiology. At the cellular level, the mammalian clock consists of autoregulatory feedback loops involving a set of "clock genes," including the Cryptochrome (Cry) genes, Cry1 and Cry2. Experimental evid...

journal_title：Journal of biological rhythms

authors： Evans JA,Pan H,Liu AC,Welsh DK

更新日期：2012-12-01 00:00:00

abstract：:The circadian clock plays an important role in adaptation in time and space by synchronizing changes in physiological, developmental, and behavioral traits of organisms with daily and seasonal changes in their environment. We have studied some features of the circadian activity and clock organization in a northern Dro...

journal_title：Journal of biological rhythms

authors： Kauranen H,Menegazzi P,Costa R,Helfrich-Förster C,Kankainen A,Hoikkala A

更新日期：2012-10-01 00:00:00

abstract：:Honey bee (Apis mellifera) workers emerge from the pupae with no circadian rhythms in behavior or brain clock gene expression but show strong rhythms later in life. This postembryonic development of circadian rhythms is reminiscent of that of infants of humans and other primates but contrasts with most insects, which ...

journal_title：Journal of biological rhythms

authors： Eban-Rothschild A,Shemesh Y,Bloch G

更新日期：2012-06-01 00:00:00

abstract：:Honey bee workers care for ("nurse") the brood around the clock without circadian rhythmicity, but then they forage outside with strong circadian rhythms and a consolidated nightly rest. This chronobiological plasticity is associated with variation in the expression of the canonical "clock genes" that regulate the cir...

journal_title：Journal of biological rhythms

authors： Rodriguez-Zas SL,Southey BR,Shemesh Y,Rubin EB,Cohen M,Robinson GE,Bloch G

更新日期：2012-02-01 00:00:00

abstract：:Intertidal species have both circadian and circatidal clocks. Although the behavioral evidence for these oscillators is more than 5 decades old, virtually nothing is known about their molecular clockwork. Pigment-dispersing hormones (PDHs) were originally described in crustaceans. Their insect homologs, pigment-disper...

journal_title：Journal of biological rhythms

authors： Beckwith EJ,Lelito KR,Hsu YW,Medina BM,Shafer O,Ceriani MF,de la Iglesia HO

更新日期：2011-12-01 00:00:00

abstract：:While the rapid development of personal computers and high-throughput recording systems for circadian rhythms allow chronobiologists to produce huge amounts of data, the software to analyze them often lags behind. Here, we announce newly developed chronobiology software that is easy to use, compatible with many differ...

journal_title：Journal of biological rhythms

authors： Schmid B,Helfrich-Förster C,Yoshii T

更新日期：2011-10-01 00:00:00

abstract：:Photoreception in the mammalian retina is not restricted to rods and cones but extends to a small number of intrinsically photosensitive retinal ganglion cells expressing the photopigment melanopsin. These mRGCs are especially important contributors to circadian entrainment, the pupil light reflex, and other so-called...

journal_title：Journal of biological rhythms

authors： Enezi Ja,Revell V,Brown T,Wynne J,Schlangen L,Lucas R

更新日期：2011-08-01 00:00:00

abstract：:The mammalian circadian clock is known to be entrained by both a daily light-dark cycle and daily feeding cycle. However, the mechanisms of feeding-induced entrainment are not as fully understood as those of light entrainment. To elucidate the first step of entrainment of the liver clock, we identified the circadian c...

journal_title：Journal of biological rhythms

authors： Tahara Y,Otsuka M,Fuse Y,Hirao A,Shibata S

更新日期：2011-06-01 00:00:00

abstract：:The mammalian circadian clock in the suprachiasmatic nucleus (SCN) drives and maintains 24-h physiological rhythms, the phases of which are set by the local environmental light-dark cycle. Gastrin-releasing peptide (GRP) communicates photic phase setting signals in the SCN by increasing neurophysiological activity of ...

journal_title：Journal of biological rhythms

authors： Gamble KL,Kudo T,Colwell CS,McMahon DG

更新日期：2011-04-01 00:00:00

abstract：:Although overt diurnal rhythms of behavior do not begin until well after birth, molecular studies suggest that the circadian clock may begin much earlier at a cellular level: mouse embryonic fibroblasts, for example, already possess robust clocks. By multiple criteria, we found no circadian clock present in mouse embr...

journal_title：Journal of biological rhythms

authors： Kowalska E,Moriggi E,Bauer C,Dibner C,Brown SA

更新日期：2010-12-01 00:00:00

abstract：:The mammalian endogenous circadian clock, the suprachiasmatic nuclei, receives environmental inputs, namely the light-dark cycle, through photopigments located in the eye and from melanopsin-expressing retinal ganglion cells. The authors investigated the influence of light wavelength and intensity on the synchronizati...

journal_title：Journal of biological rhythms

authors： Perret M,Gomez D,Barbosa A,Aujard F,Théry M

更新日期：2010-06-01 00:00:00

abstract：:African sleeping sickness is characterized by alterations in rhythmic functions. It is not known if the disease affects the expression of clock genes, which are the molecular basis for rhythm generation. We used a chronic rat model of experimental sleeping sickness, caused by the extracellular parasite Trypanosoma bru...

journal_title：Journal of biological rhythms

authors： Lundkvist GB,Sellix MT,Nygård M,Davis E,Straume M,Kristensson K,Block GD

更新日期：2010-04-01 00:00:00

abstract：:Activity patterns are the product of interactions between an internal circadian clock and direct responses to photic and nonphotic features of the environment that are said to "mask" the influence of that clock. Evolutionary transitions between nocturnality and diurnality involve changes in mechanisms underlying both ...

journal_title：Journal of biological rhythms

authors： Cohen R,Smale L,Kronfeld-Schor N

更新日期：2010-02-01 00:00:00

abstract：:Seasonal changes in numerous aspects of mammalian immune function arise as a result of the annual variation in environmental day length (photoperiod), but it is not known if absolute photoperiod or relative change in photoperiod drives these changes. This experiment tested the hypothesis that an individual's history o...

journal_title：Journal of biological rhythms

authors： Prendergast BJ,Pyter LM

更新日期：2009-12-01 00:00:00

abstract：:How the cellular elements of the SCN are synchronized to each other is not well understood. We explore circadian oscillations manifest at the level of the cell, the tissue, and the whole animal to better understand intra-SCN synchrony and master clock function of the nucleus. At each level of analysis, responses to va...

journal_title：Journal of biological rhythms

authors： Butler MP,Silver R

更新日期：2009-10-01 00:00:00

abstract：:A 24-h treatment with the cytokine tumor necrosis factor-alpha (TNF-alpha) suppresses transcription of E-box-driven clock genes (D-site albumin promoter binding protein, Dbp; Tyrotroph embryonic factor, Tef ; Hepatic leukemia factor, Hlf; Period homolog to Drosophila 1/2/3, Per1, Per2, and Per3) by yet unknown molecul...

journal_title：Journal of biological rhythms

authors： Petrzilka S,Taraborrelli C,Cavadini G,Fontana A,Birchler T

更新日期：2009-08-01 00:00:00

abstract：:Subjective well-being largely depends on mood, which shows circadian rhythmicity and can be linked to rhythms in many physiological circadian markers, such as melatonin and cortisol. In healthy young volunteers mood is influenced by an interaction of circadian phase and the duration of time awake. The authors analyzed...

journal_title：Journal of biological rhythms

authors： Birchler-Pedross A,Schröder CM,Münch M,Knoblauch V,Blatter K,Schnitzler-Sack C,Wirz-Justice A,Cajochen C

更新日期：2009-06-01 00:00:00

abstract：:Many mammalian cell types show daily rhythms in gene expression driven by a circadian pacemaker. For example, cultured astrocytes display circadian rhythms in Period1 and Period2 expression. It is not known, however, how or which intercellular factors synchronize and sustain rhythmicity in astrocytes. Because astrocyt...

journal_title：Journal of biological rhythms

authors： Marpegan L,Krall TJ,Herzog ED

更新日期：2009-04-01 00:00:00

abstract：:Reduced sensitivity to short-wavelength (blue) light with age has been shown for light-induced melatonin suppression. The current research aimed to determine if a similar age-related reduction occurs in subjective alertness, mood, and circadian phase-advancing responses. Young (n = 11, 23.0 +/- 2.9 years) and older (n...

journal_title：Journal of biological rhythms

authors： Sletten TL,Revell VL,Middleton B,Lederle KA,Skene DJ

更新日期：2009-02-01 00:00:00

abstract：:Crustaceans have frequently been used to study the neuroethology of both agonistic behavior and circadian rhythms, but whether their highly stereotyped and quantifiable agonistic activity is controlled by circadian pacemakers has, so far, not been investigated. Isolated marbled crayfish (Procambarus spec.) displayed r...

journal_title：Journal of biological rhythms

authors： Farca Luna AJ,Hurtado-Zavala JI,Reischig T,Heinrich R

更新日期：2009-02-01 00:00:00

abstract：:Since the advent of techniques to investigate gene expression on a large scale, numerous circadian rhythms in mRNA amount have been reported. These rhythms generally differ in amplitude and phase. The authors investigated how far a parameter not regulated by the circadian clock can influence the phase of a rhythm in R...

journal_title：Journal of biological rhythms

authors： Jacobshagen S,Kessler B,Rinehart CA

更新日期：2008-12-01 00:00:00

abstract：:During the first 7 weeks of postnatal life, short day lengths inhibit the onset of puberty in many photoperiodic rodents, but not in Syrian hamsters. In this species, timing of puberty and fecundity are independent of the early postnatal photoperiod. Gestational day length affects postnatal reproductive development in...

journal_title：Journal of biological rhythms

authors： Beery AK,Paul MJ,Routman DM,Zucker I

更新日期：2008-10-01 00:00:00

abstract：:The daily biological clock regulates the timing of sleep and physiological processes that are of fundamental importance to human health, performance, and well-being. Environmental parameters of relevance to biological clocks include (1) daily fluctuations in light intensity and temperature, and (2) seasonal changes in...

journal_title：Journal of biological rhythms

authors： Ciarleglio CM,Ryckman KK,Servick SV,Hida A,Robbins S,Wells N,Hicks J,Larson SA,Wiedermann JP,Carver K,Hamilton N,Kidd KK,Kidd JR,Smith JR,Friedlaender J,McMahon DG,Williams SM,Summar ML,Johnson CH

更新日期：2008-08-01 00:00:00

abstract：:The Drosophila clock relies on transcriptional feedback loops that generate daily oscillations of the clock gene expression at mRNA and protein levels. In the evening, the CLOCK (CLK) and CYCLE (CYC) basic helix-loop-helix (bHLH) PAS-domain transcription factors activate the expression of the period (per) and timeless...

journal_title：Journal of biological rhythms

authors： Richier B,Michard-Vanhée C,Lamouroux A,Papin C,Rouyer F

更新日期：2008-04-01 00:00:00

abstract：:Siberian hamsters (Phodopus sungorus) exhibit changes in immune function following adaptation to short photoperiods, including a marked attenuation of energetically expensive thermoregulatory and behavioral responses to gram-negative bacterial infections. Whether this seasonal attenuation of the immune response is idi...

journal_title：Journal of biological rhythms

authors： Baillie SR,Prendergast BJ

更新日期：2008-02-01 00:00:00

abstract：:The light preferences of fruit flies were tested by 2 different means. First, flies were allowed to choose between different illuminations, and their favorite resting, grooming, and feeding places were determined with an infrared-sensitive camera. Second, the activity levels of the animals during their main daily acti...

journal_title：Journal of biological rhythms

authors： Rieger D,Fraunholz C,Popp J,Bichler D,Dittmann R,Helfrich-Förster C

更新日期：2007-10-01 00:00:00

abstract：:The temporal expression pattern of the circadian clock gene period was compared between heads of the linden bug, Pyrrhocoris apterus , kept under diapause-promoting short days (SD) and diapause-preventing long days (LD) using a real-time PCR quantification. Diapause or reproduction was programmed by photoperiod during...

journal_title：Journal of biological rhythms

authors： Dolezel D,Sauman I,Kost'ál V,Hodkova M

更新日期：2007-08-01 00:00:00

abstract：:Two major approaches have been used to model circadian clocks. Qualitative modeling, used prior to the recent wealth of detailed molecular knowledge, makes general predictions but cannot provide detailed mechanistic insights. The more recent biophysical approach, on the other hand, incorporates the biochemical events ...

journal_title：Journal of biological rhythms

authors： Forger D,Gonze D,Virshup D,Welsh DK

更新日期：2007-06-01 00:00:00

abstract：:The SCN has long had organizational schemas imposed on it. In most, the SCN is dichotomized, with one region typically associated with the presence of vasopressin cells and the other associated with cells containing vasoactive intestinal polypeptide and certain afferent terminal fields. If assumed to be accurate, the ...

journal_title：Journal of biological rhythms

authors： Morin LP

更新日期：2007-02-01 00:00:00

abstract：:The circadian system in higher organisms temporally orchestrates rhythmic changes in a vast number of genes and gene products in different organs. Complex interactions between these components, both within and among cells, ultimately lead to rhythmic behavior and physiology. Identifying the plethora of circadian targe...

journal_title：Journal of biological rhythms

authors： De Haro L,Panda S

更新日期：2006-12-01 00:00:00

abstract：:Abstract The cyanobacterial clock protein KaiC regulates the circadian cycle by exhibiting rhythms in transcription, translation, and phosphorylation. KaiC phosphorylation persists in circadian cycling even under transcription-less conditions and was reconstituted in vitro by incubating KaiC, KaiA, and KaiB. This pres...

journal_title：Journal of biological rhythms

authors： Takigawa-Imamura H,Mochizuki A

更新日期：2006-10-01 00:00:00

abstract：:The circadian pacemaker of the SCN is a heterogeneous structure containing many single-cell oscillators that display phase differences in gene expression and electrical activity rhythms. Thus far, it is unknown how single neurons contribute to the population signal measured from the SCN. The authors used single-unit e...

journal_title：Journal of biological rhythms

authors： Rohling J,Wolters L,Meijer JH

更新日期：2006-08-01 00:00:00

abstract：:The role of the intergeniculate leaflet of the thalamus (IGL) in photoperiod responsiveness was examined in a laboratory-selected line of photoperiod nonresponsive (NR) Siberian hamsters. NR hamsters fail to exhibit typical winter-type responses (i.e., gonadal regression and development of winter-type pelage) when exp...

journal_title：Journal of biological rhythms

authors： Freeman DA,Teubner BJ,Goldman BD

更新日期：2006-06-01 00:00:00

abstract：:Drosophila littoralis is a latitudinally widespread European species of the Drosophila virilis group. The species has ample genetic variation in photoperiodism (adult diapause) and circadian rhythmicity (pupal eclosion rhythm), with adaptive latitudinal clines in both of them. The possible common genetic basis between...

journal_title：Journal of biological rhythms

authors： Lankinen P,Forsman P

更新日期：2006-02-01 00:00:00

abstract：:The retinohypothalamic tract (RHT), a monosynaptic retinal projection to the SCN, is the major path by which light entrains the circadian system to the external photoperiod. The circadian system of rodents effectively integrates or counts photons, and the magnitude of the rhythm phase response is proportional to the t...

journal_title：Journal of biological rhythms

authors： Muscat L,Morin LP

更新日期：2005-12-01 00:00:00

abstract：:DEC1 and DEC2-basic helix-loop-helix transcription factors-exhibit a circadian expression in the suprachiasmatic nucleus and other peripheral tissues and seem to play roles in regulating the mammalian circadian rhythm by suppressing the CLOCK/BMAL1-activated promoters of Per1, Dec1, and Dec2. The authors present data ...

journal_title：Journal of biological rhythms

authors： Noshiro M,Furukawa M,Honma S,Kawamoto T,Hamada T,Honma K,Kato Y

更新日期：2005-10-01 00:00:00

abstract：:In our attempts to understand the circadian system, we unavoidably rely on abstractions. Instead of describing the behavior of the circadian system in all its complexity, we try to derive basic features from which we form a global concept on how the system works. Such a basic concept is a model of reality. The author ...

journal_title：Journal of biological rhythms

authors： Beersma DG

更新日期：2005-08-01 00:00:00

abstract：:Odors elicit a number of behavioral responses, including attraction and repulsion in Drosophila. In this study, the authors used a T-maze apparatus to show that wild-type Drosophila melanogaster exhibit a robust circadian rhythm in the olfactory attractive and repulsive responses. These responses were lower during the...

journal_title：Journal of biological rhythms

authors： Zhou X,Yuan C,Guo A

更新日期：2005-06-01 00:00:00